Here is list of the best tips to make your WordPress Website run the best.

• Make sure you running the latest wordpress release (you should be doing this for security reasons anyway)
• Use a caching plugin (W3 Total Cache or Quick Cache)
• Optimize and Repair your Database from myPhpAdmin or with a plug in
• Make sure you keep your images sizes as small as possible
• Use good hosting
• Don’t use more plugins than you need
• Use a lighter theme if possible
• Keep page sizes as small as possible
• Add far future expires header to images, CSS and javascript files (plugin or .htaccess
• Use gzip compression (plugin or .htaccess
• Kill spam comment (plugin or .htaccess

WordPress is a great platform for your website or blog but does require more server resources than traditional html based websites.